Non-17α-alkylated testosterone derivatives such as testosterone itself, DHT, and dev-members.writeappreviews.com nandrolone all have poor oral bioavailability due to extensive first-pass hepatic metabolism and hence are not orally active. Similarly to the case of estrogenic activity, the progestogenic activity of these drugs serves to augment their antigonadotropic activity. Many 19-nortestosterone derivatives,…...